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Best Supplements for IBS

  • Gut Health Herbs & Compounds
  • 5 min read
  • Aug 17, 2023 - Evinature
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IBS is considered a functional digestive disorder, likely caused by a disruption in the brain-gut axis (the communication between gut bacteria and the nervous system). Low-grade inflammation and gut barrier permeability are also highly implicated in IBS symptoms. 

Functional medicine offers interventions for IBS that involve diet and specific lifestyle changes, as well as herbal remedies and supplements that naturally improve the health and diversity of gut bacteria, target low-grade inflammation, and fortify the gut barrier.

Here’s a breakdown of the best supplements to take for IBS, according to the latest research.  

Peppermint Oil for IBS 

Peppermint has been used as a herbal medicine for stomach pain and digestion since ancient Egypt. 

The popular folk remedy may be especially helpful for IBS patients as it relaxes the muscles of the intestinal tract, reducing contractions that are too fast in patients with diarrhea-predominant IBS. In 2019, researchers analyzed the pooled data from 12 randomized trials. They found peppermint oil to be a safe and effective remedy for IBS symptoms.

Peppermint can alleviate symptoms such as bloating, diarrhea, and gas, and has been found in clinical trials to significantly improve quality of life. But of all the symptoms, peppermint oil is especially effective in reducing abdominal pain, as it can activate an “anti-pain” channel in the colon called TRPM8 and reduce pain-sensing fibers.

How to Use Peppermint Oil for IBS 

You can steep peppermint leaves in tea, but it is most effective for stomach-related issues when concentrated into oil and taken orally in enteric-coated capsules, which allows it to pass into the intestine.

Probiotics for IBS 

Probiotics are live microorganisms that support the trillions of bacteria in the body and help “good” bacteria thrive. As IBS is considered a brain-gut axis disorder, any natural supplement that improves the health and balance of our gut bacteria may benefit those with IBS.

That said, there are many probiotic strains that will affect each individual differently, so it helps to find a strain that was tested in clinical trials for your exact symptoms. Research on probiotics for IBS symptoms has mainly focused on two strains: Lactobacillus and Bifidobacterium

Lactobacillus acidophilus NCFM® may relieve bloating and abdominal pain (Faber, SM. 2000) by activating μ-opioid and cannabinoid receptors in the intestine. 

Lactobacillus acidophilus DDS-1 has been found to improve symptom severity, quality of life, and perceived stress levels. Lactobacillus plantarum 299v showed similar improvements for IBS, especially for abdominal pain, flatulence, diarrhea, and constipation. 

Bfidobacterium bifidum MIMBb75 may also relieve IBS symptoms, notably pain, discomfort, bloating, urgency, and overall quality of life. Bifidobacterium infantis 35624 was found to alleviate abdominal pain, bowel dysfunction, incomplete evacuation, straining, and gas. 

How to Use Probiotics for IBS 

Although there is promising evidence for probiotics for IBS, it’s best to consult with your doctor or dietician to select the right probiotic strain for your specific needs. A broad-spectrum probiotic supplement will not target specific symptoms but may improve general gut health. You can also boost your gut health by consuming probiotic foods such as fermented food like miso, kimchi, and yogurt. 

L-Glutamine for IBS 

Glutamine is an amino acid that plays a vital role in protecting the lining of the gastrointestinal tract – the mucosa. It does so by regulating tight junction proteins, which form the seal between adjacent cells of the mucosa, making up the barrier between the interior and exterior of the intestinal tube. 

When tight junctions lose their structural integrity, it allows microorganisms to cross the gut barrier. This can trigger infection and inflammation, a condition many refer to as ‘gut barrier permeability’ or ‘leaky gut’. GI conditions like IBD and IBS are both associated with decreased expression of tight junctions and the resulting permeability. 

Studies show that L-Glutamine can improve post-infectious IBS and enhance the efficacy of the Low FODMAP Diet, although more research is needed to confirm the exact benefits of L-glutamine for IBS. Still, as the supplement improves gut barrier permeability and inflammation, it may offer general health improvements for most IBS patients. 

How to Use L-Glutamine for IBS 

Studies generally use 5 grams of glutamine three times a day, with the higher doses reaching up to 40 grams per day. As always, it’s best to consult with your doctor as they will be able to recommend the most suitable dose for your condition and background. 

Curcumin for IBS 

Curcumin is a powerful anti-inflammatory and anti-oxidant compound extracted from turmeric, famed for its manifold benefits to gut health. But can it help with IBS? 

A 2018 meta-analysis found that curcumin was beneficial for IBS patients and relieved many of their symptoms. Curcumin likely works by reducing interleukin-6, a pro-inflammatory cytokine found high in IBS patients. Curcumin also exerts mucosal protective effects by increasing the expression of tight junction proteins

How to Use Curcumin for IBS 

When taking curcumin for IBS or any digestive symptoms, it’s important to purchase 95% concentrated curcumin that is not boosted in bioavailability. Curcumin products with high bioavailability will absorb into the bloodstream before it reaches the intestine. Non-boosted curcumin makes direct contact with the intestinal walls and therefore offers the most benefit to IBS patients. 

A Tailored Approach is the Best Approach  

While many supplements have shown promise for IBS, it’s important to consult with your doctor or dietician before making any treatment decisions. Supplements and doses need to be tailored to each individual’s specific condition and personal needs, as no two bodies are the same and what works for one person may exasperate symptoms in another.   




This blog is not intended to provide diagnosis, treatment, or medical advice. The content provided is for informational purposes only. Please consult with a physician or healthcare professional regarding any medical or health related diagnosis or treatment options. The claims made regarding specific products in this blog are not approved to diagnose, treat, cure, or prevent disease.


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