Ashwagandha is derived from the Withania somnifera plant, and has a long history of being used in Ayurvedic tradition to treat everything from anxiety to inflammation to fertility. The adaptogen’s prowess at restoring balance and moderating the brain-gut axis (also known as the HPA axis) marks it as a classic suggestion for those suffering from stress-induced gut issues.
As with all things, moderation and balance is important, and it is essential to weigh the potential side effects of Ashwagandha together with the accrued benefits of this plant. It is also important to make sure to get your supplements from a reputable source, with evidence of third-party testing and quality control, such as Evinature’s Exhale nutraceutical featuring responsibly-sourced Ashwagandha.
How to use Ashwagandha safely
While Ashwagandha is generally safe to take, it is important to educate yourself on the potential risks associated (even if those risks are low).
It is important to determine which type of supplement is best for you and your lifestyle, whether it is capsule form, powder, gummies or liquid drops, and to make sure that your supplements are from a reliable and reputable source.
It is common for cheap supplements to not have checked every box in terms of their quality and testing, but Evinature’s Exhale supplement, containing Ashwagandha, is rigorously tested to ensure safe and effective use. It is important to observe changes in your body while taking the supplement, and if you are unsure about a specific symptom, always check with your doctor.
Evinature provides free support through our Clinic Support team, with advice from our representatives to help track and manage use of our supplements.
Common Side Effects
Ashwagandha is associated with few side effects, but some have been observed. Due to the regulation of the HPA axis (“brain-gut connection”) it can cause mild digestive discomfort, such as diarrhea, vomiting or nausea.
It can also cause drowsiness or fatigue, and may impact the effect of certain hormone-altering or thyroid medications; therefore, always consult with your doctor before taking an Ashwagandha supplement, and reach out for guidance if you observe any unusual or severe side effects.
Ashwagandha is associated with the following common side effects:
- Allergic reactions – Mild rash, itching, or difficulty breathing (rare but possible).
- Stomach discomfort – Bloating, cramping, or diarrhea, usually mild and temporary.
- Nausea – Some users report queasiness, especially with higher doses.
- Heart palpitations – Uncommon, but may occur in sensitive individuals.
- Liver inflammation – Rare; mostly reported in people with pre-existing liver issues.
- Drowsiness – A common effect due to Ashwagandha’s calming properties.
- Anxiety or irritability – Unusual but possible in some users.
- Headaches – Infrequent, typically linked to dose or supplement quality.
Who Shouldn’t take Ashwagandha
- Patients with a diagnosed liver disease: Ashwagandha has rarely been reported to be associated with inflammation of the liver (hepatitis) which could lead to jaundice and/or liver damage, especially in patients who already suffer from a liver disease. Do not take Ashwagandha if you have a known liver disease.
- Patients with hyperthyroidism: Theoretically, Ashwagandha increases thyroid function and elevates hormone levels. Therefore, patients with hyperthyroidism or other thyroid issues should consult a medical professional before taking.
Interactions and special conditions
Ashwagandha may interact with specific medications. It is essential to consult your treating physician if you are on one or more of the following drugs:
- Sedatives and anti-anxiety drugs (may enhance drowsiness);
- Thyroid medications (may increase thyroid hormone activity);
- Immunosuppressants (may reduce their effectiveness);
- Blood sugar or blood pressure medications (can amplify their effects);
- Alcohol: Combining the two may increase drowsiness or liver strain; avoid concurrent use.
Ashwagandha is not recommended for people with hyperthyroidism, as it may further stimulate thyroid hormone production.
Caution for autoimmune diseases such as lupus, multiple sclerosis, or rheumatoid arthritis, should be taken, as ashwagandha may activate the immune system.
Avoid during pregnancy — ashwagandha may increase the risk of uterine contractions or miscarriage.
Always consult your healthcare provider before using ashwagandha, especially if you have a chronic condition or are taking prescription medications.
Summer Pitocchelli-Schwartzman
